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Fosamax

Fosamax is a bisphosphonate manufactured by Merck and used to treat osteoporosis and decreased bone density in postmenopausal women. The drug has been shown to cause osteonecrosis (ONJ) of the jaw, or “dead jaw.” Osteonecrosis is a slow death of bone tissue that occurs because of poor blood supply to the bone. The deterioration is painful and often characterized by mouth swelling, loosening of teeth and exposed bone. Patients who have undergone chemotherapy, taken Fosamax intravenously, have a history of cancer, Paget’s disease or osteoporosis, use steroids while on Fosamax or have a history of major dental work are at an increased risk for ONJ. Other side effects include a risk of severe stomach ulcers when used in conjunction with Naproxin.

Fast Facts

Name: Fosamax
Generic: Sodium alendronate
Manufacturer: Merck & Co.
Date approved: 2001
Status: Prescription only
Approved uses: Osteoporosis prevention and treatment
Off-Label uses: N/A
Side effects: Osteonecrosis (ONJ) of the jaw ("dead jaw syndrome"), esophageal disorders, bone pain and swelling
Related topics: Unsafe drugs, Vioxx, bisphosphonates

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Alendronate (Fosamax) Risks Alarm Doctors

With recent allegations that mega-pharmaceutical corporation Merck's second best-selling drug, Fosamax and Fosamax D, causes bone death (osteonecrosis) of the jaw, the effectiveness... read more

Fosamax and Men - Risks and Warnings

With the recent bombshell that Fosamax , Merck & Co.'s second best-selling drug, causes bone death (also known as osteonecrosis [ONJ] or dead jaw syndrome ) of the... read more

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FDA Information Related to Fosamax

FDA Approves Updated Warfarin (Coumadin) Prescribing Information

Information on Bisphosphonates

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Government Articles Related to Fosamax

SUMMARY OF SAFETY-RELATED DRUG LABELING CHANGES APPROVED BY FDA, April 1997

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MSN Newsfeeds Related to Fosamax

FDA Approves Generic Versions Of Fosamax

Three generic versions of Fosamax now offered to osteoporosis patients

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News Articles Related to Fosamax

Fosamax, Merck's other drug problem

Merck moves to overturn Teva win in weekly Fosamax case

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Patents Related to Fosamax

Method for inhibiting bone resorption

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Useful Web Sites Related to Fosamax

Anapol Schwartz, Fosamax Attorneys

The Wikipedia Alendronate Page

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Wikipedia Entries Related to Fosamax

Alendronate

Bisphosphonate

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Books Related to Fosamax

Fosamax: A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

Functionalized bisphosphonate extractants: A structure-property relationship study

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